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MGP003157

Record overview

MGPD IDMGP003157
Gene ID7122
SpeciesHomo sapiens (Human)
Gene Nameclaudin 5
Gene Symbol CLDN5
SynonymsAWAL; BEC1; TMVCF; CPETRL1;
Alternate namesclaudin-5; TMDVCF; transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome;
Chromosome22
Map Location22q11.21
SummaryThis gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
OrthologsView orthologs and multiple alignments for CLDN5

Proteins

claudin-5
Refseq ID:NP_003268
Protein GI:195947372
UniProt ID:O00501
mRNA ID:NM_003277
Length:303
RefSeq Status:
MTRARIGCFGPGGRARGTESAPEPSKRVPPGRSWQTQEVRQTRGANGLGPRAGSAGAKAPGPAQGAAQHGLGGSAGLRVRVSPLAMGSAALEILGLVLCL
VGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCKVYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGPAKA
RVALTGGVLYLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCGAWVCTGRPDLSFPVKYSAPRRPTATGDYDKK
NYV
 
claudin-5
Refseq ID:NP_001124333
Protein GI:195947374
UniProt ID:O00501
mRNA ID:NM_001130861
Length:303
RefSeq Status:
Protein sequence is identical to GI:195947372 (mRNA isoform)
 
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