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MGP003184

UniProt Annotations

Entry Information
Gene Nametropomyosin 4
Protein EntryTPM4_HUMAN
UniProt IDP67936
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P67936-1, P07226-1; Sequence=Displayed; Name=2; IsoId=P67936-2, P07226-2; Sequence=VSP_006611;
DomainThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269|PubMed:1836432}.
SimilarityBelongs to the tropomyosin family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton.
SubunitHeterodimer of an alpha and a beta chain. {ECO:0000250}.
Tissue SpecificityDetected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269|PubMed:1836432}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TPM4ID359.html";
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