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MGP003212

UniProt Annotations

Entry Information
Gene Nametranslin-associated factor X
Protein EntryTSNAX_HUMAN
UniProt IDQ99598
SpeciesHuman
Comments
Comment typeDescription
FunctionActs in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}.
PtmSumoylated with SUMO1. {ECO:0000269|PubMed:15561718}.
SimilarityBelongs to the translin family. {ECO:0000305}.
Subcellular LocationCytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.
SubunitRing-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma- radiation. Interacts with TSN and C1D in a mutually exclusive manner. {ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:15919079, ECO:0000269|PubMed:21552258, ECO:0000269|PubMed:9013868}.
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