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MGP003250

Record overview

MGPD IDMGP003250
Gene ID7332
SpeciesHomo sapiens (Human)
Gene Nameubiquitin-conjugating enzyme E2L 3
Gene Symbol UBE2L3
SynonymsE2-F1; L-UBC; UBCH7; UbcM4;
Alternate namesubiquitin-conjugating enzyme E2 L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme UBCH7; ubiquitin-protein ligase L3;
Chromosome22
Map Location22q11.21
EC Number6.3.2.19
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for UBE2L3

Proteins

ubiquitin-conjugating enzyme E2 L3 isoform 1
Refseq ID:NP_003338
Protein GI:4507789
UniProt ID:P68036
mRNA ID:NM_003347
Length:154
RefSeq Status:
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATK
TDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
 
ubiquitin-conjugating enzyme E2 L3 isoform 3
Refseq ID:NP_001243285
Protein GI:373432682
UniProt ID:P68036
mRNA ID:NM_001256356
Length:122
RefSeq Status:
MAASRRLMKDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKD
RKKFCKNAEEFTKKYGEKRPVD
 
ubiquitin-conjugating enzyme E2 L3 isoform 4
Refseq ID:NP_001243284
Protein GI:373432684
UniProt ID:P68036
mRNA ID:NM_001256355
Length:212
RefSeq Status:
MQVAAGTRGDTRLQEVALLPQLFDLLVLGQRRARLLRQVPSALAGKDLAQLQAGATLAGYRRAHGPEELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPD
NPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEE
FTKKYGEKRPVD
 
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