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MGP003277

UniProt Annotations

Entry Information
Gene Nameubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Protein EntryUCRI_HUMAN
UniProt IDP47985
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityQuinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000255|PROSITE-ProRule:PRU00628}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|PROSITE- ProRule:PRU00628};
FunctionComponent of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
FunctionThe transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. {ECO:0000250}.
MiscellaneousThe Rieske protein is a high potential 2Fe-2S protein.
SimilarityContains 1 Rieske domain. {ECO:0000255|PROSITE- ProRule:PRU00628}.
Subcellular LocationMitochondrion inner membrane; Single-pass membrane protein.
SubunitThe bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
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