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MGP003426

Record overview

MGPD IDMGP003426
Gene ID7884
SpeciesHomo sapiens (Human)
Gene Namestem-loop binding protein
Gene Symbol SLBP
SynonymsHBP;
Alternate nameshistone RNA hairpin-binding protein; hairpin binding protein, histone; histone binding protein; histone stem-loop binding protein; histone stem-loop-binding protein; stem-loop (histone) binding protein;
Chromosome4
Map Location4p16.3
SummaryThis gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SLBP

Proteins

histone RNA hairpin-binding protein
Refseq ID:NP_006518
Protein GI:5729862
UniProt ID:Q14493
mRNA ID:NM_006527
Length:270
RefSeq Status:
MACRPRSPPRHQSRCDGDASPPSPARWSLGRKRRADGRRWRPEDAEEAEHRGAERRPESFTTPEGPKPRSRCSDWASAVEEDEMRTRVNKEMARYKRKLL
INDFGRERKSSSGSSDSKESMSTVPADFETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPKTPNKFKKYSRRSWDQQIKLWKVALHFWDPP
AEEGCDLQEIHPVDLESAESSSEPQTSSQDDFDVYSGTPTKVRHMDSQVEDEFDLEACLTEPLRDFSAMS
 
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