MGP Database

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MGP003451

Ontology/Pathway Information

Entrez Gene ID8085
Gene Namelysine (K)-specific methyltransferase 2D
Gene Symbol KMT2D
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0035097 IPI:MGIChistone methyltransferase complex
GO:0005634 NAS:UniProtKBCnucleus
GO:0003677 NAS:UniProtKBFDNA binding
GO:0018024 IEA:UniProtKB-ECFhistone-lysine N-methyltransferase activity
GO:0044212 IDA:UniProtKBFtranscription regulatory region DNA binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0006342 ISS:UniProtKBPchromatin silencing
GO:0051568 ISS:UniProtKBPhistone H3-K4 methylation
GO:0001555 ISS:UniProtKBPoocyte growth
GO:0048477 ISS:UniProtKBPoogenesis
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0033148 IMP:UniProtKBPpositive regulation of intracellular estrogen receptor signaling pathway
GO:0045944 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006355 NAS:UniProtKBPregulation of transcription, DNA-templated
GO:0043627 IDA:UniProtKBPresponse to estrogen
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264165Chromatin modifying enzymes
REACT_264155Chromatin organization
REACT_264178deactivation of the beta-catenin transactivating complex
REACT_116125Disease
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_268728PKMTs methylate histone lysines
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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