MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003458

UniProt Annotations

Entry Information
Gene Nameacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Protein EntryAN32A_HUMAN
UniProt IDP39687
SpeciesHuman
Comments
Comment typeDescription
FunctionImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:17557114}.
InteractionO15169:AXIN1; NbExp=2; IntAct=EBI-359234, EBI-710484; Q66K89:E4F1; NbExp=3; IntAct=EBI-359234, EBI-1227043; P67775:PPP2CA; NbExp=2; IntAct=EBI-359234, EBI-712311; P63331:Ppp2ca (xeno); NbExp=2; IntAct=EBI-359234, EBI-7050205;
PtmPhosphorylated on serine residues. {ECO:0000269|PubMed:18669648}.
PtmSome glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). {ECO:0000250}.
PtmThe N-terminus is blocked.
Sequence CautionSequence=BAD97000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the ANP32 family. {ECO:0000305}.
SimilarityContains 1 LRRCT domain. {ECO:0000305}.
SimilarityContains 4 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250}.
SubunitComponent of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B. Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1. {ECO:0000269|PubMed:11163245, ECO:0000269|PubMed:11555662, ECO:0000269|PubMed:11729309, ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:17557114}.
Tissue SpecificityExpressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. {ECO:0000269|PubMed:15642345}.
  logo