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MGP003471

UniProt Annotations

Entry Information
Gene Nameubiquitin specific peptidase 11
Protein EntryUBP11_HUMAN
UniProt IDP51784
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityThiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). {ECO:0000269|PubMed:12084015}.
CautionIt is uncertain whether Met-1 or Met-44 is the initiator. {ECO:0000305}.
FunctionProtease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. {ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889, ECO:0000269|PubMed:20233726}.
InteractionP35226:BMI1; NbExp=7; IntAct=EBI-306876, EBI-2341576; Q9HC52:CBX8; NbExp=5; IntAct=EBI-306876, EBI-712912; P03129:E7 (xeno); NbExp=6; IntAct=EBI-306876, EBI-866453; Q9DLK6:NP (xeno); NbExp=3; IntAct=EBI-306876, EBI-8433218; P15659:PA (xeno); NbExp=2; IntAct=EBI-306876, EBI-8431752; P35227:PCGF2; NbExp=5; IntAct=EBI-306876, EBI-2129767; Q06587:RING1; NbExp=4; IntAct=EBI-306876, EBI-752313; Q99496:RNF2; NbExp=4; IntAct=EBI-306876, EBI-722416; P04608:tat (xeno); NbExp=3; IntAct=EBI-306876, EBI-6164389;
Sequence CautionSequence=AAC50450.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC50450.1; Type=Frameshift; Positions=65, 117, 134, 146; Evidence={ECO:0000305}; Sequence=BAC20463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD20056.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase C19 family. {ECO:0000305}.
SimilarityContains 1 DUSP domain. {ECO:0000255|PROSITE- ProRule:PRU00613}.
SimilarityContains 1 USP domain. {ECO:0000305}.
Subcellular LocationNucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.
SubunitInteracts with RANBP9/RANBPM. Interacts with BRCA2, CHUK/IKKA and NFKBIA. Interacts with papilloma virus protein 16E7. {ECO:0000269|PubMed:12084015, ECO:0000269|PubMed:15314155, ECO:0000269|PubMed:17897950, ECO:0000269|PubMed:18408009, ECO:0000269|PubMed:19874889}.
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