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MGP003508

Record overview

MGPD IDMGP003508
Gene ID8346
SpeciesHomo sapiens (Human)
Gene Namehistone cluster 1, H2bi
Gene Symbol HIST1H2BI
SynonymsH2B/k; H2BFK;
Alternate nameshistone H2B type 1-C/E/F/G/I; H2B histone family, member K; histone 1, H2bi; histone H2B.1 A; histone H2B.k;
Chromosome6
Map Location6p22.2
SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jan 2015]
OrthologsView orthologs and multiple alignments for HIST1H2BI

Proteins

histone H2B type 1-C/E/F/G/I
Refseq ID:NP_003516
Protein GI:4504271
UniProt ID:P62807
mRNA ID:NM_003525
Length:126
RefSeq Status:
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVR
LLLPGELAKHAVSEGTKAVTKYTSSK
 
mat_peptide: 1..126
product: histone cluster 1, H2bi
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12860195]
calculated_mol_wt: 13906
peptide sequence: 
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVR
LLLPGELAKHAVSEGTKAVTKYTSSK
 
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