MGP Database

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MGP003579

Ontology/Pathway Information

Entrez Gene ID8517
Gene Nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Symbol IKBKG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0008385 TAS:UniProtKBCIkappaB kinase complex
GO:0005622 IDA:LIFEdbCintracellular
GO:0072686 IDA:UniProtKBCmitotic spindle
GO:0005634 IDA:UniProtKBCnucleus
GO:0000922 IDA:UniProtKBCspindle pole
GO:0000151 IPI:ParkinsonsUK-UCLCubiquitin ligase complex
GO:0070530 IBA:GO_CentralFK63-linked polyubiquitin binding
GO:1990450 IDA:ParkinsonsUK-UCLFlinear polyubiquitin binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0019904 IPI:UniProtKBFprotein domain specific binding
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0004871 TAS:ProtIncFsignal transducer activity
GO:0031625 IPI:ParkinsonsUK-UCLFubiquitin protein ligase binding
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0007250 IEA:EnsemblPactivation of NF-kappaB-inducing kinase activity
GO:0006915 TAS:ProtIncPapoptotic process
GO:0001782 IEA:EnsemblPB cell homeostasis
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0051650 IMP:UniProtKBPestablishment of vesicle localization
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0007249 TAS:UniProtKBPI-kappaB kinase/NF-kappaB signaling
GO:0006955 TAS:ProtIncPimmune response
GO:0006954 TAS:UniProtKBPinflammatory response
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0007254 TAS:ReactomePJNK cascade
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:1901215 TAS:ParkinsonsUK-UCLPnegative regulation of neuron death
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:0043123 IDA:MGIPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032481 TAS:ReactomePpositive regulation of type I interferon production
GO:0009615 TAS:UniProtKBPresponse to virus
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0050852 NAS:UniProtKBPT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_6890Activated TLR4 signalling
REACT_118656Activation of NF-kappaB in B cells
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_25374IKK complex recruitment mediated by RIP1
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_24918IRAK1 recruits IKK complex
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21308MAP kinase activation in TLR cascade
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_22232Signaling by Interleukins
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_12526TCR signaling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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