MGP Database

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MGP003656

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
Protein EntryB4GT4_HUMAN
UniProt IDO60513
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=238 uM for GlcNAc-B-S-pNP {ECO:0000269|PubMed:11588157};
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide. {ECO:0000269|PubMed:9792633}.
Catalytic ActivityUDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. {ECO:0000269|PubMed:9792633}.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionResponsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. {ECO:0000269|PubMed:9792633}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 7 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Tissue SpecificityHigh expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Beta-1,4-galactosyltransferase 4; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_439";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALT4";
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