MGP Database

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MGP003661

Ontology/Pathway Information

Entrez Gene ID8720
Gene Namemembrane-bound transcription factor peptidase, site 1
Gene Symbol MBTPS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005788 TAS:ProtIncCendoplasmic reticulum lumen
GO:0005789 IEA:UniProtKB-SubCellCendoplasmic reticulum membrane
GO:0005794 IBA:GO_CentralCGolgi apparatus
GO:0000139 TAS:ReactomeCGolgi membrane
GO:0005795 IEA:EnsemblCGolgi stack
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0004252 IMP:UniProtKBFserine-type endopeptidase activity
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0008203 IEA:UniProtKB-KWPcholesterol metabolic process
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0006629 IBA:GO_CentralPlipid metabolic process
GO:0007040 IMP:UniProtKBPlysosome organization
GO:0031293 ISS:ParkinsonsUK-UCLPmembrane protein intracellular domain proteolysis
GO:0006508 IMP:UniProtKBPproteolysis
GO:0042990 IEA:EnsemblPregulation of transcription factor import into nucleus
GO:0034976 ISS:ParkinsonsUK-UCLPresponse to endoplasmic reticulum stress
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18348ATF6-alpha activates chaperones
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_17015Metabolism of proteins
REACT_147797Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_18356Unfolded Protein Response (UPR)
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