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MGP003863

UniProt Annotations

Entry Information
Gene Namegeneral transcription factor IIIC, polypeptide 4, 90kDa
Protein EntryTF3C4_HUMAN
UniProt IDQ9UKN8
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + [histone] = CoA + acetyl- [histone].
FunctionEssential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box.
Sequence CautionSequence=AAH11619.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
SimilarityBelongs to the TFIIIC subunit 4 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitPart of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C1, GTF3C2, GTF3C5, GTF3C6, POLR3C and POLR3F. {ECO:0000269|PubMed:10523658, ECO:0000269|PubMed:17409385}.
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