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MGP003886

UniProt Annotations

Entry Information
Gene NameGRB2-related adaptor protein 2
Protein EntryGRAP2_HUMAN
UniProt IDO75791
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75791-1; Sequence=Displayed; Name=2; IsoId=O75791-2; Sequence=VSP_055234, VSP_055235; Note=No experimental confirmation available.;
FunctionInteracts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
InteractionP00533:EGFR; NbExp=2; IntAct=EBI-740418, EBI-297353; P04626:ERBB2; NbExp=2; IntAct=EBI-740418, EBI-641062; Q08460:Kcnma1 (xeno); NbExp=3; IntAct=EBI-740418, EBI-1633915; P10721:KIT; NbExp=2; IntAct=EBI-740418, EBI-1379503; Q13094:LCP2; NbExp=11; IntAct=EBI-740418, EBI-346946; Q9H3S7:PTPN23; NbExp=8; IntAct=EBI-740418, EBI-724478;
SimilarityBelongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 2 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationNucleus {ECO:0000269|PubMed:21179510}. Cytoplasm {ECO:0000269|PubMed:21179510}. Endosome {ECO:0000269|PubMed:21179510}.
SubunitInteracts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23. {ECO:0000250, ECO:0000269|PubMed:10811803, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12359715, ECO:0000269|PubMed:21179510}.
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