MGP Database

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MGP003901

Record overview

MGPD IDMGP003901
Gene ID9440
SpeciesHomo sapiens (Human)
Gene Namemediator complex subunit 17
Gene Symbol MED17
SynonymsCRSP6; CRSP77; DRIP80; TRAP80;
Alternate namesmediator of RNA polymerase II transcription subunit 17; ARC77; CRSP complex subunit 6; activator-recruited cofactor 77 kDa component; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; thyroid hormone receptor-associated protein complex 80 kDa component; transcriptional coactivator CRSP77; vitamin D3 receptor-interacting protein complex 80 kDa component;
Chromosome11
Map Location11q14
SummaryThe activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MED17

Proteins

mediator of RNA polymerase II transcription subunit 17
Refseq ID:NP_004259
Protein GI:28558975
UniProt ID:Q9NVC6
mRNA ID:NM_004268
Length:651
RefSeq Status:
MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRN
NLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVG
DKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQN
VLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPF
GHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVE
QIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQ
CKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
 
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