MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003976

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 5B
Protein EntryIF2P_HUMAN
UniProt IDO60841
SpeciesHuman
Comments
Comment typeDescription
FunctionFunction in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). {ECO:0000250}.
InteractionO14602:EIF1AY; NbExp=2; IntAct=EBI-928530, EBI-286439; P14921:ETS1; NbExp=2; IntAct=EBI-928530, EBI-913209;
Sequence CautionSequence=BAA34461.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
SimilarityContains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU01059}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts with ANXA5 in a calcium and phospholipid- dependent manner. {ECO:0000250}.
  logo