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MGP004033

UniProt Annotations

Entry Information
Gene Namemembrane associated guanylate kinase, WW and PDZ domain containing 2
Protein EntryMAGI2_HUMAN
UniProt IDQ86UL8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86UL8-1; Sequence=Displayed; Name=2; IsoId=Q86UL8-2; Sequence=VSP_008435;
FunctionSeems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269|PubMed:10760291}.
InteractionP08588:ADRB1; NbExp=2; IntAct=EBI-311035, EBI-991009;
Sequence CautionSequence=BAA31680.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the MAGUK family. {ECO:0000305}.
SimilarityContains 1 guanylate kinase-like domain. {ECO:0000255|PROSITE-ProRule:PRU00100}.
SimilarityContains 2 WW domains. {ECO:0000255|PROSITE- ProRule:PRU00224}.
SimilarityContains 6 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule:PRU00143}.
Subcellular LocationCytoplasm {ECO:0000250}. Late endosome {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity). {ECO:0000250}.
SubunitInteracts (via its WW domains) with DRPLA. Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C- terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a NGF-dependent manner (By similarity). Interacts with RAPGEF2; the interaction occurs before or after nerve growth factor (NGF) stimulation (By similarity). Interacts (via PDZ domain) with KIDINS220 (via C-terminal domain) (By similarity). Interacts with DDN. {ECO:0000250, ECO:0000269|PubMed:10760291, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:16464232, ECO:0000269|PubMed:9647693}.
Tissue SpecificitySpecifically expressed in brain. {ECO:0000269|PubMed:9647693}.
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