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MGP Database

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MGP004110

UniProt Annotations

Entry Information

Gene Name	snurportin 1
Protein Entry	SPN1_HUMAN
UniProt ID	O95149
Species	Human

Comments

Comment type	Description
Function	Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. {ECO:0000269\|PubMed:9670026}.
Similarity	Belongs to the snurportin family. {ECO:0000305}.
Similarity	Contains 1 IBB domain. {ECO:0000255\|PROSITE- ProRule:PRU00561}.
Subcellular Location	Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta. It is re- exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway.
Subunit	Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with DDX20, IPO7, KPNB1, SMN1, SNRPB and XPO1. Interacts directly with XPO1. Its interaction with XPO1 and binding to m3G-cap U snRNPs appears to be mutually exclusive. {ECO:0000269\|PubMed:10209022, ECO:0000269\|PubMed:12095920, ECO:0000269\|PubMed:15920472, ECO:0000269\|PubMed:9670026}.