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MGP004164

UniProt Annotations

Entry Information
Gene NameInaD-like (Drosophila)
Protein EntryINADL_HUMAN
UniProt IDQ8NI35
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8NI35-1; Sequence=Displayed; Name=2; IsoId=Q8NI35-2; Sequence=VSP_014205, VSP_014207; Name=3; IsoId=Q8NI35-3; Sequence=VSP_014207; Name=4; IsoId=Q8NI35-4; Sequence=VSP_014206, VSP_014207; Name=5; IsoId=Q8NI35-5; Sequence=VSP_014204, VSP_014208, VSP_014209;
DomainThe L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions.
DomainThe PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization.
FunctionScaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. {ECO:0000269|PubMed:11927608}.
InteractionP82279:CRB1; NbExp=2; IntAct=EBI-724390, EBI-1048648; Q8N3R9:MPP5; NbExp=4; IntAct=EBI-724390, EBI-2513978; P35240:NF2; NbExp=2; IntAct=EBI-724390, EBI-1014472;
Sequence CautionSequence=CAH70416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21733.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 10 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 1 L27 domain. {ECO:0000255|PROSITE- ProRule:PRU00365}.
Subcellular LocationMembrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane. {ECO:0000250}.
SubunitInteracts with ASIC3, KCNJ10, KCNJ15, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NLGN2, MPP7, HTR2A and SLC6A4 (By similarity). Forms a ternary complex with MPP5, CRB1 and CRB3. Interacts with TJP3/ZO-3 and CLDN1/claudin-1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Directly interacts with HTR4 (By similarity). Interacts (via PDZ domain 8) with WWC1 (via the ADDV motif). {ECO:0000250, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:12021270, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:18596123}.
Tissue SpecificityExpressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. {ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:9280290}.
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