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MGP004183

Record overview

MGPD IDMGP004183
Gene ID10266
SpeciesHomo sapiens (Human)
Gene Namereceptor (G protein-coupled) activity modifying protein 2
Gene Symbol RAMP2
Alternate namesreceptor activity-modifying protein 2; CRLR activity-modifying protein 2; calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2; receptor (calcitonin) activity modifying protein 2; receptor activity modifying protein 2; receptor-activity-modifying protein 2;
Chromosome17
Map Location17q12-q21.1
SummaryThe protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RAMP2

Proteins

receptor activity-modifying protein 2 precursor
Refseq ID:NP_005845
Protein GI:118572585
UniProt ID:O60895
mRNA ID:NM_005854
Length:175
RefSeq Status:
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCL
EHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA
 
sig_peptide: 1..35
calculated_mol_wt: 3751
peptide sequence: 
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVL

mat_peptide: 36..175
product: receptor activity-modifying protein 2
calculated_mol_wt: 15875
peptide sequence: 
NPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQ
PTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA
 
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