MGP Database

MGP004283

Record overview

MGPD ID	MGP004283
Gene ID	10555
Species	Homo sapiens (Human)
Gene Name	1-acylglycerol-3-phosphate O-acyltransferase 2
Gene Symbol	AGPAT2
Synonyms	BSCL; BSCL1; LPAAB; 1-AGPAT2; LPAAT-beta;
Alternate names	1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-AGP acyltransferase 2; 1-AGPAT 2; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta;
Chromosome	9
Map Location	9q34.3
EC Number	2.3.1.51
Summary	This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for AGPAT2

Proteins

1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a precursor

Refseq ID:	NP_006403
Protein GI:	6041665
UniProt ID:	O15120
mRNA ID:	NM_006412
Length:	278
RefSeq Status:

`MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQS ILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIV PVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ`

1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b precursor
`sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2551 peptide sequence: MELWPCLAAALLLLLLLVQLSRA`

Refseq ID:	NP_001012745
Protein GI:	69122971
UniProt ID:	O15120
mRNA ID:	NM_001012727
Length:	246
RefSeq Status:

`MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQS ILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIP TSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ`

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2551
peptide sequence: 
MELWPCLAAALLLLLLLVQLSRA

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2551
peptide sequence: 
MELWPCLAAALLLLLLLVQLSRA