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MGP004293

UniProt Annotations

Entry Information
Gene Namechaperonin containing TCP1, subunit 2 (beta)
Protein EntryTCPB_HUMAN
UniProt IDP78371
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P78371-1; Sequence=Displayed; Name=2; IsoId=P78371-2; Sequence=VSP_042648; Note=No experimental confirmation available.;
FunctionMolecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.
InteractionQ8IWZ6:BBS7; NbExp=3; IntAct=EBI-357407, EBI-1806001;
SimilarityBelongs to the TCP-1 chaperonin family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:20080638}.
SubunitHeterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. {ECO:0000269|PubMed:14532270, ECO:0000269|PubMed:20080638}.
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