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MGP004326

Record overview

MGPD IDMGP004326
Gene ID10667
SpeciesHomo sapiens (Human)
Gene Namephenylalanyl-tRNA synthetase 2, mitochondrial
Gene Symbol FARS2
SynonymsFARS1; PheRS; COXPD14; HSPC320; dJ520B18.2;
Alternate namesphenylalanine--tRNA ligase, mitochondrial; dJ236A3.1 (phenylalanine-tRNA synthetase); dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)); phenylalanine tRNA ligase 2, mitochondrial; phenylalanine translase; phenylalanine-tRNA synthetase 1 (mitochondrial);
Chromosome6
Map Location6p25.1
EC Number6.1.1.20
SummaryAminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for FARS2

Proteins

phenylalanine--tRNA ligase, mitochondrial precursor
Refseq ID:NP_006558
Protein GI:5729820
UniProt ID:O95363
mRNA ID:NM_006567
Length:451
RefSeq Status:
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQ
YVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLF
SKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLID
KFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF
 
transit_peptide: 1..36
calculated_mol_wt: 3973
peptide sequence: 
MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRP

mat_peptide: 37..451
product: phenylalanine--tRNA ligase, mitochondrial
calculated_mol_wt: 48402
peptide sequence: 
PAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHP
SRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAV
KLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCED
ERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQA
LQEAAVQLLGVEGRF
 
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