MGP Database

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MGP004379

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 46, subfamily A, polypeptide 1
Protein EntryCP46A_HUMAN
UniProt IDQ9Y6A2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y6A2-1; Sequence=Displayed; Name=2; IsoId=Q9Y6A2-2; Sequence=VSP_053859; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y6A2-3; Sequence=VSP_053858, VSP_053860; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=2.2 uM for 24(S)-hydroxycholesterol {ECO:0000269|PubMed:14640697};
Catalytic ActivityCholesterol + NADPH + O(2) = (24S)-24- hydroxycholesterol + NADP(+) + H(2)O. {ECO:0000269|PubMed:18621681}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828, ECO:0000269|PubMed:23288837};
FunctionInvolved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue SpecificityExpressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.
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