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MGP004517

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha 11
Protein EntryITA11_HUMAN
UniProt IDQ9UKX5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKX5-1; Sequence=Displayed; Name=2; IsoId=Q9UKX5-2; Sequence=VSP_053416;
Developmental StageStrongly up-regulated in differentiating fetal muscle cells (in vitro).
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-11/beta-1 is a receptor for collagen.
Sequence CautionSequence=AAL39001.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21. {ECO:0000269|PubMed:16754960}.
Tissue SpecificityAccording to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver. {ECO:0000269|PubMed:10464311}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ITGA11ID41001ch15q23.html";
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