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MGP004639

UniProt Annotations

Entry Information
Gene Namecytoplasmic linker associated protein 1
Protein EntryCLAP1_HUMAN
UniProt IDQ7Z460
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q7Z460-1; Sequence=Displayed; Name=2; IsoId=Q7Z460-2; Sequence=VSP_022386, VSP_022387, VSP_022389; Name=3; IsoId=Q7Z460-3; Sequence=VSP_022386, VSP_022387, VSP_022388, VSP_022389; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z460-4; Sequence=VSP_054412, VSP_054413, VSP_022386, VSP_054414, VSP_022389; Note=No experimental confirmation available.; Name=5; IsoId=Q7Z460-5; Sequence=VSP_057272, VSP_022386, VSP_022387, VSP_022389; Note=No experimental confirmation available.;
FunctionMicrotubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:12837247, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864}.
InteractionQ9JK25:Clip1 (xeno); NbExp=2; IntAct=EBI-913476, EBI-908338; O55156:Clip2 (xeno); NbExp=3; IntAct=EBI-913476, EBI-349416; O60333:KIF1B; NbExp=3; IntAct=EBI-913476, EBI-465633; Q96R06:SPAG5; NbExp=3; IntAct=EBI-913476, EBI-413317;
Sequence CautionSequence=AAH32563.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX88872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the CLASP family. {ECO:0000305}.
SimilarityContains 7 HEAT repeats. {ECO:0000255|PROSITE- ProRule:PRU00103}.
Subcellular LocationCytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
SubunitInteracts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity). {ECO:0000250}.
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