MGP Database

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MGP004647

UniProt Annotations

Entry Information
Gene Nameribosomal RNA processing 8, methyltransferase, homolog (yeast)
Protein EntryRRP8_HUMAN
UniProt IDO43159
SpeciesHuman
Comments
Comment typeDescription
FunctionEssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}.
InteractionQ96EB6:SIRT1; NbExp=3; IntAct=EBI-2008793, EBI-1802965; O43463:SUV39H1; NbExp=3; IntAct=EBI-2008793, EBI-349968;
Sequence CautionSequence=BAA23705.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the methyltransferase superfamily. RRP8 family. {ECO:0000305}.
Subcellular LocationNucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.
SubunitComponent of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. {ECO:0000269|PubMed:18485871}.
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