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MGP004769

UniProt Annotations

Entry Information
Gene Nameanti-silencing function 1A histone chaperone
Protein EntryASF1A_HUMAN
UniProt IDQ9Y294
SpeciesHuman
Comments
Comment typeDescription
FunctionHistone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251}.
InteractionP03372:ESR1; NbExp=2; IntAct=EBI-749553, EBI-78473;
PtmPhosphorylated by TLK1 and TLK2. Highly phosphorylated in S- phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation. {ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:20016786}.
SimilarityBelongs to the ASF1 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904}.
SubunitInteracts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP. {ECO:0000269|PubMed:10759893, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12093919, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14680630, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:15840725, ECO:0000269|PubMed:16980972, ECO:0000269|PubMed:19029251, ECO:0000269|PubMed:22407294, ECO:0000269|PubMed:24616510}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:12842904}.
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