MGP Database

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MGP004907

UniProt Annotations

Entry Information
Gene Namelinker for activation of T cells
Protein EntryLAT_HUMAN
UniProt IDO43561
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Long; IsoId=O43561-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=O43561-2; Sequence=VSP_004303; Name=3; IsoId=O43561-3; Sequence=VSP_054758, VSP_004303; Note=Gene prediction based on EST data.; Name=4; IsoId=O43561-4; Sequence=VSP_054759, VSP_004303; Name=5; IsoId=O43561-5; Sequence=VSP_054759;
FunctionRequired for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
InteractionP00533:EGFR; NbExp=2; IntAct=EBI-1222766, EBI-297353; P62993:GRB2; NbExp=12; IntAct=EBI-1222766, EBI-401755; P06239:LCK; NbExp=2; IntAct=EBI-1222766, EBI-1348; P27986:PIK3R1; NbExp=4; IntAct=EBI-1222766, EBI-79464; P08487:PLCG1 (xeno); NbExp=4; IntAct=EBI-8070286, EBI-8013886; P19174:PLCG1; NbExp=6; IntAct=EBI-1222766, EBI-79387; P18031:PTPN1; NbExp=3; IntAct=EBI-1222766, EBI-968788;
MiscellaneousEngagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell- induced activation of PLC, maybe by inducing the dephosphorylation of LAT.
PtmPalmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. {ECO:0000269|PubMed:9729044}.
PtmPhosphorylated on tyrosines by ZAP70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Phosphorylated by ITK leading to the recruitment of VAV1 to LAT-containing complexes.
Subcellular LocationCell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
SubunitWhen phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
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