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MGP004921

Record overview

MGPD IDMGP004921
Gene ID27123
SpeciesHomo sapiens (Human)
Gene Namedickkopf WNT signaling pathway inhibitor 2
Gene Symbol DKK2
SynonymsDKK-2;
Alternate namesdickkopf-related protein 2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2; dickkopf-2; hDkk-2;
Chromosome4
Map Location4q25
SummaryThis gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DKK2

Proteins

dickkopf-related protein 2 precursor
Refseq ID:NP_055236
Protein GI:7657023
UniProt ID:Q9UBU2
mRNA ID:NM_014421
Length:259
RefSeq Status:
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSAC
MVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFW
TKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
 
sig_peptide: 1..33
calculated_mol_wt: 3443
peptide sequence: 
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRA

mat_peptide: 34..259
product: dickkopf-related protein 2
calculated_mol_wt: 25022
peptide sequence: 
KLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES
ILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDC
AKGLSCKVWKDATYSSKARLHVCQKI
 
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