MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004946

Record overview

MGPD IDMGP004946
Gene ID27243
SpeciesHomo sapiens (Human)
Gene Namecharged multivesicular body protein 2A
Gene Symbol CHMP2A
SynonymsBC2; BC-2; VPS2; CHMP2; VPS2A;
Alternate namescharged multivesicular body protein 2a; VPS2 homolog A; chromatin modifying protein 2A; putative breast adenocarcinoma marker (32kD); putative breast adenocarcinoma marker BC-2; vacuolar protein sorting-associated protein 2-1; vps2-1;
Chromosome19
Map Location19q
SummaryCHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for CHMP2A

Proteins

charged multivesicular body protein 2a
Refseq ID:NP_940818
Protein GI:38372933
UniProt ID:O43633
mRNA ID:NM_198426
Length:222
RefSeq Status:
MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMA
QAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEA
AASALADADADLEERLKNLRRD
 
charged multivesicular body protein 2a
Refseq ID:NP_055268
Protein GI:7656922
UniProt ID:O43633
mRNA ID:NM_014453
Length:222
RefSeq Status:
Protein sequence is identical to GI:38372933 (mRNA isoform)
 
  logo