MGP Database

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MGP004996

UniProt Annotations

Entry Information
Gene Namesecretogranin III
Protein EntrySCG3_HUMAN
UniProt IDQ8WXD2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WXD2-1; Sequence=Displayed; Name=2; IsoId=Q8WXD2-2; Sequence=VSP_042876; Note=No experimental confirmation available.;
PolymorphismPolymorphisms in the 5'-flanking region and in intron 1 may have an effect on transcriptional activity and be associated with an increase in subcutaneous, but not visceral, fat area. Hence, may influence the risk of obesity.
PtmO-glycosylated. {ECO:0000269|PubMed:23234360}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions (By similarity). Neuroendocrine and endocrine secretory granules. {ECO:0000250}.
SubunitInteracts with CHGA. {ECO:0000250}.
Tissue SpecificityExpressed in brain, heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:12098761}.
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