MGP Database

MGP005059

Ontology/Pathway Information

Entrez Gene ID	50507
Gene Name	NADPH oxidase 4
Gene Symbol	NOX4
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0005789	IEA:UniProtKB-SubCell	C	endoplasmic reticulum membrane
GO:0005925	IEA:UniProtKB-SubCell	C	focal adhesion
GO:0016021	TAS:UniProtKB	C	integral component of membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0043020	IEA:Ensembl	C	NADPH oxidase complex
GO:0005730	IEA:UniProtKB-SubCell	C	nucleolus
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0001725	IEA:Ensembl	C	stress fiber
GO:0009055	TAS:UniProtKB	F	electron carrier activity
GO:0050660	TAS:UniProtKB	F	flavin adenine dinucleotide binding
GO:0020037	TAS:UniProtKB	F	heme binding
GO:0072341	IDA:UniProtKB	F	modified amino acid binding
GO:0016174	TAS:UniProtKB	F	NAD(P)H oxidase activity
GO:0000166	TAS:UniProtKB	F	nucleotide binding
GO:0019826	TAS:UniProtKB	F	oxygen sensor activity
GO:0016175	IEA:Ensembl	F	superoxide-generating NADPH oxidase activity
GO:0045453	IEA:Ensembl	P	bone resorption
GO:0055007	IEA:Ensembl	P	cardiac muscle cell differentiation
GO:0007569	ISS:UniProtKB	P	cell aging
GO:0000902	ISS:UniProtKB	P	cell morphogenesis
GO:0071320	IEA:Ensembl	P	cellular response to cAMP
GO:0071480	IEA:Ensembl	P	cellular response to gamma radiation
GO:0071333	IEA:Ensembl	P	cellular response to glucose stimulus
GO:0071560	IEA:Ensembl	P	cellular response to transforming growth factor beta stimulus
GO:0050667	IDA:UniProtKB	P	homocysteine metabolic process
GO:0006954	TAS:UniProtKB	P	inflammatory response
GO:0008285	ISS:UniProtKB	P	negative regulation of cell proliferation
GO:0055114	IDA:UniProtKB	P	oxidation-reduction process
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:2000573	IEA:Ensembl	P	positive regulation of DNA biosynthetic process
GO:0070374	IEA:Ensembl	P	positive regulation of ERK1 and ERK2 cascade
GO:0043406	IEA:Ensembl	P	positive regulation of MAP kinase activity
GO:0051897	IEA:Ensembl	P	positive regulation of protein kinase B signaling
GO:2000379	IEA:Ensembl	P	positive regulation of reactive oxygen species metabolic process
GO:0014911	IEA:Ensembl	P	positive regulation of smooth muscle cell migration
GO:0051496	IEA:Ensembl	P	positive regulation of stress fiber assembly
GO:0072593	IDA:UniProtKB	P	reactive oxygen species metabolic process
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0042554	ISS:UniProtKB	P	superoxide anion generation

SMP Pathway Links

SMP ID	Description
SMP00716	Thyroid hormone synthesis