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MGP005099

Record overview

MGPD IDMGP005099
Gene ID51023
SpeciesHomo sapiens (Human)
Gene Namemitochondrial ribosomal protein S18C
Gene Symbol MRPS18C
SynonymsCGI-134; S18mt-c; MRPS18-1; mrps18-c; MRP-S18-1; MRP-S18-c;
Alternate names28S ribosomal protein S18c, mitochondrial; 28S ribosomal protein S18-1, mitochondrial; mitochondrial ribosomal protein S18-1;
Chromosome4
Map Location4q21.23
SummaryMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MRPS18C

Proteins

28S ribosomal protein S18c, mitochondrial isoform 1
Refseq ID:NP_057151
Protein GI:7705630
UniProt ID:Q9Y3D5
mRNA ID:NM_016067
Length:142
RefSeq Status:
MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQLLSQFVSPFTGCIYGRHITGLC
GKKQKEITKAIKRAQIMGFMPVTYKDPAYLKDPKVCNIRYRE
 
28S ribosomal protein S18c, mitochondrial isoform 2
Refseq ID:NP_001284696
Protein GI:663071180
UniProt ID:D6RCM2
mRNA ID:NM_001297767
Length:114
RefSeq Status:
MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLLLSQFVSPFTGCIYGRHITGLCGKKQKEITKAIKRAQIMGFMPVTYKDPA
YLKDPKVCNIRYRE
 
28S ribosomal protein S18c, mitochondrial isoform 3
Refseq ID:NP_001284698
Protein GI:663071184
UniProt ID:Q9Y3D5
mRNA ID:NM_001297769
Length:96
RefSeq Status:
MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLPISMENPYKEPLKKCILCGKHVDYKNVQVFVGRNRKKSQKQLRELK
 
28S ribosomal protein S18c, mitochondrial isoform 4
Refseq ID:NP_001284699
Protein GI:663071186
UniProt ID:Q9Y3D5
mRNA ID:NM_001297770
Length:68
RefSeq Status:
MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRRGCSQQVSSNEDLVFVGRNRKKSQKQLRELK
 
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