MGP Database

MGP005106

Record overview

MGPD ID	MGP005106
Gene ID	51067
Species	Homo sapiens (Human)
Gene Name	tyrosyl-tRNA synthetase 2, mitochondrial
Gene Symbol	YARS2
Synonyms	TYRRS; CGI-04; MLASA2; MT-TYRRS;
Alternate names	tyrosine--tRNA ligase, mitochondrial; tyrosine tRNA ligase 2, mitochondrial;
Chromosome	12
Map Location	12p11.21
EC Number	6.1.1.1
Summary	This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Orthologs	View orthologs and multiple alignments for YARS2

Proteins

tyrosine--tRNA ligase, mitochondrial precursor

Refseq ID:	NP_001035526
Protein GI:	94681057
UniProt ID:	Q9Y2Z4
mRNA ID:	NM_001040436
Length:	477
RefSeq Status:

MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFH
LQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLS
RQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSE
FFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL

transit_peptide: 1..16
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9Y2Z4.2)
calculated_mol_wt: 1822
peptide sequence: 
MAAPILRSFSWGRWSG

mat_peptide: 17..477
product: Tyrosine--tRNA ligase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9Y2Z4.2)
calculated_mol_wt: 51395
peptide sequence: 
TLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGAT
ARLGDPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSL
AEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVER
YLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKA
NAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL