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MGP005108

UniProt Annotations

Entry Information
Gene Namenitric oxide synthase interacting protein
Protein EntryNOSIP_HUMAN
UniProt IDQ9Y314
SpeciesHuman
Comments
Comment typeDescription
DomainThe U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
FunctionNegatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.
SimilarityBelongs to the NOSIP family. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.
SubunitInteracts with NOS1 and NOS3. {ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660}.
Tissue SpecificityExpressed in heart, brain and lung. Present in endothelial cells (at protein level). {ECO:0000269|PubMed:11149895}.
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