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MGP005110

Record overview

MGPD IDMGP005110
Gene ID51073
SpeciesHomo sapiens (Human)
Gene Namemitochondrial ribosomal protein L4
Gene Symbol MRPL4
SynonymsL4mt; CGI-28;
Alternate names39S ribosomal protein L4, mitochondrial; MRP-L4;
Chromosome19
Map Location19p13.2
SummaryMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MRPL4

Proteins

39S ribosomal protein L4, mitochondrial isoform a
Refseq ID:NP_057040
Protein GI:22547136
UniProt ID:Q9BYD3
mRNA ID:NM_015956
Length:311
RefSeq Status:
MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVA
MWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDP
QYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFPRPLPHA
TQGPAATPYHC
 
39S ribosomal protein L4, mitochondrial isoform a
Refseq ID:NP_666499
Protein GI:22547138
UniProt ID:Q9BYD3
mRNA ID:NM_146387
Length:311
RefSeq Status:
Protein sequence is identical to GI:22547136 (mRNA isoform)
 
39S ribosomal protein L4, mitochondrial isoform b
Refseq ID:NP_666500
Protein GI:22547140
UniProt ID:Q9BYD3
mRNA ID:NM_146388
Length:263
RefSeq Status:
MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVA
MWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDP
QYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGEQRAQAPRVRMCRLRC
 
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