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MGP005209

UniProt Annotations

Entry Information
Gene Nameantizyme inhibitor 1
Protein EntryAZIN1_HUMAN
UniProt IDO14977
SpeciesHuman
Comments
Comment typeDescription
FunctionAntizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269|PubMed:17900240}.
PtmUbiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1. {ECO:0000269|PubMed:17900240}.
SimilarityBelongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitMonomer. Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation.
Tissue SpecificityExpressed in liver.
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