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MGP005268

UniProt Annotations

Entry Information
Gene Namedual oxidase 1
Protein EntryDUOX1_HUMAN
UniProt IDQ9NRD9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRD9-1; Sequence=Displayed; Name=2; IsoId=Q9NRD9-2; Sequence=VSP_017262, VSP_017263; Note=No experimental confirmation available.;
Catalytic ActivityNAD(P)H + O(2) = NAD(P)(+) + H(2)O(2). {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:15972824}.
Developmental StageWidely expressed in fetal tissues. {ECO:0000269|PubMed:11514595}.
Enzyme RegulationThe NADPH oxidase activity is calcium- dependent. Peroxidase activity is inhibited by aminobenzohydrazide. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:15972824}.
FunctionGenerates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.
InductionBy forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:16111680}.
PathwayHormone biosynthesis; thyroid hormone biosynthesis.
PtmN-glycosylated. {ECO:0000269|PubMed:11822874}.
Sequence CautionSequence=AK128591; Type=Erroneous termination; Positions=967; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAD18816.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule:PRU00716}.
SimilarityContains 1 ferric oxidoreductase domain. {ECO:0000305}.
SimilarityContains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityIn the N-terminal section; belongs to the peroxidase family. {ECO:0000305}.
Subcellular LocationApical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi- pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.
SubunitInteracts with TXNDC11, TPO and CYBA. {ECO:0000269|PubMed:15561711}.
Tissue SpecificityExpressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283, ECO:0000269|PubMed:15210697}.
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