MGP Database

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MGP005284

UniProt Annotations

Entry Information
Gene Namesolute carrier family 38, member 2
Protein EntryS38A2_HUMAN
UniProt IDQ96QD8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QD8-1; Sequence=Displayed; Name=2; IsoId=Q96QD8-2; Sequence=VSP_029553, VSP_029554;
Biophysicochemical PropertiesKinetic parameters: KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0);
Enzyme RegulationInhibited by N-methyl-D-glucamine and probably choline. {ECO:0000269|PubMed:10930503}.
FunctionFunctions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15922329}.
InductionUp-regulated upon hypertonic conditions and amino acid deprivation. {ECO:0000269|PubMed:14623874, ECO:0000269|PubMed:15922329, ECO:0000269|PubMed:16621798}.
MiscellaneousDepletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.
PtmPolyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. {ECO:0000250}.
Sequence CautionSequence=BAD18765.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the amino acid/polyamine transporter 2 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}; Multi-pass membrane protein {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.
Tissue SpecificityUbiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}.
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