MGP Database

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MGP005332

UniProt Annotations

Entry Information
Gene Nametransient receptor potential cation channel, subfamily M, member 7
Protein EntryTRPM7_HUMAN
UniProt IDQ96QT4
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
DiseaseAmyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionEssential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671}.
PtmAutophosphorylated. {ECO:0000250}.
Sequence CautionSequence=BAC11462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18773.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 alpha-type protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00501}.
SimilarityIn the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitHomodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6. {ECO:0000250, ECO:0000269|PubMed:14976260}.
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