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MGP005501

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 10 (soluble)
Protein EntryADCYA_HUMAN
UniProt IDQ96PN6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96PN6-1; Sequence=Displayed; Name=2; IsoId=Q96PN6-2; Sequence=VSP_030867; Note=No experimental confirmation available.; Name=3; IsoId=Q96PN6-3; Sequence=VSP_030866, VSP_030868, VSP_030869, VSP_030870; Note=No experimental confirmation available.; Name=4; IsoId=Q96PN6-4; Sequence=VSP_046329; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.8 mM for ATP-Mn(2+) {ECO:0000269|PubMed:12609998}; KM=2.41 mM for Mg(2+) {ECO:0000269|PubMed:12609998};
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
DiseaseHypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {ECO:0000269|PubMed:11932268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Enzyme RegulationActivated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium. {ECO:0000269|PubMed:15659711}.
FunctionSoluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. {ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
PtmCleavage may occur to generate the active 48 kDa form.
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationCell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Tissue SpecificityWeakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. {ECO:0000269|PubMed:11932268, ECO:0000269|PubMed:15659711, ECO:0000269|PubMed:17591988}.
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