MGP Database

MGP005571

Record overview

MGPD ID	MGP005571
Gene ID	56937
Species	Homo sapiens (Human)
Gene Name	prostate transmembrane protein, androgen induced 1
Gene Symbol	PMEPA1
Synonyms	STAG1; TMEPAI;
Alternate names	protein TMEPAI; prostate transmembrane protein androgen induced 1; solid tumor-associated 1 protein; transmembrane, prostate androgen induced RNA;
Chromosome	20
Map Location	20q13.31-q13.33
Summary	This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Orthologs	View orthologs and multiple alignments for PMEPA1

Proteins

protein TMEPAI isoform a

Refseq ID:	NP_064567
Protein GI:	21361841
UniProt ID:	Q969W9
mRNA ID:	NM_020182
Length:	287
RefSeq Status:

`MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVS GNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSA RLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL`

protein TMEPAI isoform b
`sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2139 peptide sequence: MMVMVVVITCLLSHYKLSA`

Refseq ID:	NP_954638
Protein GI:	40317616
UniProt ID:	Q5JY37
mRNA ID:	NM_199169
Length:	252
RefSeq Status:

`MAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQP TYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEV IGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL`

protein TMEPAI isoform c precursor
`sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2139 peptide sequence: MMVMVVVITCLLSHYKLSA`

Refseq ID:	NP_954639
Protein GI:	40317618
UniProt ID:	Q5JY37
mRNA ID:	NM_199170
Length:	237
RefSeq Status:

`MMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTI SLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSS GPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL`

protein TMEPAI isoform c precursor
`sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2139 peptide sequence: MMVMVVVITCLLSHYKLSA`

Refseq ID:	NP_954640
Protein GI:	40317620
UniProt ID:	Q969W9
mRNA ID:	NM_199171
Length:	237
RefSeq Status:

Protein sequence is identical to GI:40317618 (mRNA isoform)

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA

protein TMEPAI isoform d

Refseq ID:	NP_001242905
Protein GI:	364023812
UniProt ID:	Q969W9
mRNA ID:	NM_001255976
Length:	259
RefSeq Status:

`MPAIPAHGAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRE RFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGP PPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA