MGP Database

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MGP005592

UniProt Annotations

Entry Information
Gene Namesolute carrier family 17 (vesicular glutamate transporter), member 6
Protein EntryVGLU2_HUMAN
UniProt IDQ9P2U8
SpeciesHuman
Comments
Comment typeDescription
Developmental StageExpressed in fetal brain. {ECO:0000269|PubMed:10820226}.
FunctionMediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226, ECO:0000269|PubMed:11698620}.
SimilarityBelongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.
Tissue SpecificityPredominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269|PubMed:10820226}.
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