MGP Database

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MGP005677

UniProt Annotations

Entry Information
Gene NameMAP/microtubule affinity-regulating kinase 4
Protein EntryMARK4_HUMAN
UniProt IDQ96L34
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96L34-1; Sequence=Displayed; Name=2; Synonyms=MARKL1S; IsoId=Q96L34-2; Sequence=VSP_004946;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Enzyme RegulationActivated by phosphorylation on Thr-214. {ECO:0000269|PubMed:14976552}.
InteractionP60953:CDC42; NbExp=2; IntAct=EBI-302319, EBI-81752; Q9BYG4:PARD6G; NbExp=2; IntAct=EBI-302319, EBI-295417; Q8ND90:PNMA1; NbExp=2; IntAct=EBI-302319, EBI-302345; P41743:PRKCI; NbExp=2; IntAct=EBI-302319, EBI-286199; Q15831:STK11; NbExp=2; IntAct=EBI-302319, EBI-306838; P23258:TUBG1; NbExp=4; IntAct=EBI-302319, EBI-302589; Q04917:YWHAH; NbExp=6; IntAct=EBI-302319, EBI-306940;
PtmPhosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. {ECO:0000269|PubMed:14976552}.
PtmUbiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:18254724}.
Sequence CautionSequence=BAB47489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55238.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. {ECO:0000305}.
SimilarityContains 1 KA1 (kinase-associated) domain. {ECO:0000255|PROSITE-ProRule:PRU00565}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 UBA domain. {ECO:0000255|PROSITE- ProRule:PRU00212}.
Tissue SpecificityUbiquitous. Isoform 2 is brain-specific. {ECO:0000269|PubMed:11326310}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MARK4ID419.html";
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