MGP Database

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MGP005746

Ontology/Pathway Information

Entrez Gene ID64135
Gene Nameinterferon induced with helicase C domain 1
Gene Symbol IFIH1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003677 IEA:InterProFDNA binding
GO:0003725 IDA:UniProtKBFdouble-stranded RNA binding
GO:0004386 IEA:UniProtKB-KWFhelicase activity
GO:0043021 IPI:UniProtKBFribonucleoprotein complex binding
GO:0003727 IDA:UniProtKBFsingle-stranded RNA binding
GO:0008270 IDA:UniProtKBFzinc ion binding
GO:0039528 TAS:UniProtKBPcytoplasmic pattern recognition receptor signaling pathway in response to virus
GO:0009597 TAS:BHF-UCLPdetection of virus
GO:0045087 TAS:UniProtKBPinnate immune response
GO:0032480 TAS:ReactomePnegative regulation of type I interferon production
GO:0032727 IMP:UniProtKBPpositive regulation of interferon-alpha production
GO:0032728 IMP:UniProtKBPpositive regulation of interferon-beta production
GO:0016925 IDA:UniProtKBPprotein sumoylation
GO:0042981 IEA:InterProPregulation of apoptotic process
GO:0034344 TAS:UniProtKBPregulation of type III interferon production
GO:0009615 TAS:UniProtKBPresponse to virus
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25026TRAF3-dependent IRF activation pathway
REACT_24938TRAF6 mediated IRF7 activation
REACT_24969TRAF6 mediated NF-kB activation
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