MGP Database

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MGP005939

Ontology/Pathway Information

Entrez Gene ID79923
Gene NameNanog homeobox
Gene Symbol NANOG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005730 IDA:BHF-UCLCnucleolus
GO:0005654 IEA:EnsemblCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0003682 IEA:EnsemblFchromatin binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0001158 IEA:EnsemblFenhancer sequence-specific DNA binding
GO:0003700 IDA:HGNCFsequence-specific DNA binding transcription factor activity
GO:0003714 ISS:UniProtKBFtranscription corepressor activity
GO:0030154 IEP:HGNCPcell differentiation
GO:0008283 IMP:HGNCPcell proliferation
GO:0009880 IEA:EnsemblPembryonic pattern specification
GO:0001714 IDA:MGIPendodermal cell fate specification
GO:0008406 IEA:EnsemblPgonad development
GO:0001710 IEA:EnsemblPmesodermal cell fate commitment
GO:0030514 IEA:EnsemblPnegative regulation of BMP signaling pathway
GO:0010454 IEA:EnsemblPnegative regulation of cell fate commitment
GO:0000122 IEA:EnsemblPnegative regulation of transcription from RNA polymerase II promoter
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:0045931 IEA:EnsemblPpositive regulation of mitotic cell cycle
GO:0045944 IDA:MGIPpositive regulation of transcription from RNA polymerase II promoter
GO:0045595 IMP:HGNCPregulation of cell differentiation
GO:0010468 IMP:UniProtKBPregulation of gene expression
GO:0006355 IDA:HGNCPregulation of transcription, DNA-templated
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0035019 IMP:UniProtKBPsomatic stem cell maintenance
GO:0017145 IEA:EnsemblPstem cell division
GO:0019827 IEP:BHF-UCLPstem cell maintenance
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111045Developmental Biology
REACT_264617POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
REACT_264321POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
REACT_263856Transcriptional regulation of pluripotent stem cells
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