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MGP005985

UniProt Annotations

Entry Information
Gene Nameflavin adenine dinucleotide synthetase 1
Protein EntryFAD1_HUMAN
UniProt IDQ8NFF5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8NFF5-1; Sequence=Displayed; Name=2; IsoId=Q8NFF5-2; Sequence=VSP_027947; Name=3; IsoId=Q8NFF5-3; Sequence=VSP_027947, VSP_027954; Name=4; IsoId=Q8NFF5-4; Sequence=VSP_027948, VSP_027949, VSP_027951, VSP_027952; Name=5; IsoId=Q8NFF5-5; Sequence=VSP_027948, VSP_027949, VSP_027950, VSP_027953;
Biophysicochemical PropertiesKinetic parameters: KM=1.5 uM for FMN {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:17049878}; KM=0.36 uM for FMN (isoform 2) {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:17049878}; Vmax=6.1 nmol/min/mg enzyme {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:17049878}; Vmax=3.9 nmol/min/mg enzyme (isoform 2) {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:17049878};
Catalytic ActivityATP + FMN = diphosphate + FAD. {ECO:0000269|PubMed:16643857}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:17049878};
DomainThe molybdenum cofactor biosynthesis protein-like region may not be functional.
FunctionCatalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
PathwayCofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.
SimilarityIn the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the MoaB/Mog family. {ECO:0000305}.
Subcellular LocationIsoform 1: Mitochondrion matrix.
Subcellular LocationIsoform 2: Cytoplasm.
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