MGP Database

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MGP006139

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2 domain containing 1B
Protein EntryPPC1B_HUMAN
UniProt IDQ8NEB5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NEB5-1; Sequence=Displayed; Name=2; IsoId=Q8NEB5-2; Sequence=VSP_025241, VSP_025242; Name=3; IsoId=Q8NEB5-3; Sequence=VSP_040055; Name=4; IsoId=Q8NEB5-4; Sequence=VSP_054076, VSP_054077; Note=No experimental confirmation available. Gene prediction based on EST data.;
Biophysicochemical PropertiesKinetic parameters: KM=41 uM for diacylglycerol pyrophosphate {ECO:0000269|PubMed:17590538}; KM=277 uM for phosphatidate {ECO:0000269|PubMed:17590538}; KM=295 uM for lysophosphatidate {ECO:0000269|PubMed:17590538};
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. {ECO:0000269|PubMed:17590538}.
Enzyme RegulationInhibited by N-ethylmaleimide. {ECO:0000269|PubMed:17590538}.
FunctionDisplays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. {ECO:0000269|PubMed:16261160, ECO:0000269|PubMed:17590538}.
Sequence CautionSequence=AAI06015.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK14924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:17590538}.
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